Intestinal regeneration with less aggressive radiotherapy & More Latest News Here


Karla Santos-de-Frutos and Nabil Djouder in his laboratory./Antonio Tabernero. CNIO

Researchers of the National Cancer Research Center (CNIO) now discover one of the cellular mechanisms Y essential molecular for the regeneration of the intestinal epithelium. It is a finding that lays the foundations to stimulate this process if it fails, and to preserve it against radiotherapy either chemotherapy.

As the new result shows, prompting intestinal stem cells to regenerate the mucous membrane depends on communication between different types of cells in the epithelial tissue. Researchers have also found a way to intervene in this communication, and thus improve regeneration.

The work is published in Journal of Experimental Medicine. It is led by the head of the CNIO Growth Factors, Nutrients and Cancer Group, Nabil Djouderand has Almudena Chaves-Perez Y Karla Santos-de-Frutos as first authors.

The group has spent years researching how to improve the regeneration of various organs (particularly of the liver and intestinal mucosa), and thus palliate the effects of radiotherapy. His findings in this period have been published in journals with a high impact index.

Progenitor cells modulate mitogenic factors

“The regeneration of the intestinal epithelium is very important in the functioning of the intestine”, explains Djouder. “Until now we knew that it is promoted by powerful mitogenic factors, which stimulate the proliferation of intestinal stem cells; but we did not know how these factors are regulated”.

The current study suggests that they are the stem cells involved in regenerating the epithelial mucosa which modulate the production of mitogenic factors. The process is as follows: when severe damage occurs, stem cell injury leads to tissue inflammation; This stops the production of mitogenic factors and, consequently, the proliferation of stem cells and the consequent regeneration of the mucosa.

“This communication between, at least, four different cell types: the progenitor cells, which differentiate to form the epithelial mucosa; the cells that secrete the mitogenic factors; inflammatory cells; and the intestinal stem cells themselves,” says Djouder. “This communication must be very well controlled, so that the tissue responds adequately to aggression.”

The study opens the door to new cancer treatments

Djouder places special emphasis on the new function that, as they have observed, the progenitor cells have: “Our study suggests that the stem cells they are not simple spectators in the process of epithelial regeneration, but rather have an active role of great importance in the decisions made by intestinal stem cells in regeneration. Progenitor cells explain intestinal stem cells when and how to divide, and thus control their self-regeneration.

¨This study has allowed us to better understand the cell cooperationin order to open doors to the reduction of adverse effects in traditional cancer treatments”, say Chaves-Pérez and Santos-de-Frutos, first authors of this work.

Although it may contain statements, data or notes from health institutions or professionals, the information contained in Medical Writing is edited and prepared by journalists. We recommend the reader that any questions related to health be consulted with a health professional.

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